Publications – 2011

Ackerman, M. E., B. Moldt, R. T. Wyatt, A. S. Dugast, E. McAndrew, S. Tsoukas, S. Jost, C. T. Berger, G. Sciaranghella, Q. Liu, D. J. Irvine, D. R. Burton, and G. Alter. (2011) A robust, high-throughput assay to determine the phagocytic activity of clinical antibody samples. J Immunol Methods 366:8-19.

Agrawal, N., D. P. Leaman, E. Rowcliffe, H. Kinkead, R. Nohria, J. Akagi, K. Bauer, S. X. Du, R. G. Whalen, D. R. Burton, and M. B. Zwick. (2011) Functional Stability of Unliganded Envelope Glycoprotein Spikes among Isolates of Human Immunodeficiency Virus Type 1 (HIV-1). Plos One 6:e21339.

Bonomelli, C., K. J. Doores, D. C. Dunlop, V. Thaney, R. A. Dwek, D. R. Burton, M. Crispin, and C. N. Scanlan. (2011) The glycan shield of HIV is predominantly oligomannose independently of production system or viral clade. Plos One 6:e23521.

Burton, D. R., A. J. Hessell, B. F. Keele, P. J. Klasse, T. A. Ketas, B. Moldt, D. C. Dunlop, P. Poignard, L. A. Doyle, L. Cavacini, R. S. Veazey, and J. P. Moore. (2011) Limited or no protection by weakly or nonneutralizing antibodies against vaginal SHIV challenge of macaques compared with a strongly neutralizing antibody. Proc Natl Acad Sci USA 108:11181-11186.

Chakrabarti, B. K., L. M. Walker, J. F. Guenaga, A. Ghobbeh, P. Poignard, D. R. Burton, and R. T. Wyatt. (2011) Direct antibody access to the HIV-1 MPER positively correlates with neutralization sensitivity. J Virol 85:8217-8226.

Dorner, M., J. A. Horwitz, J. B. Robbins, W. T. Barry, Q. Feng, K. Mu, C. T. Jones, J. W. Schoggins, M. T. Catanese, D. R. Burton, M. Law, C. M. Rice, and A. Ploss. (2011) A genetically humanized mouse model for hepatitis C virus infection. Nature 474:208-211.

Du, S. X., L. Xu, W. Zhang, S. Tang, R. I. Boenig, H. Chen, E. B. Mariano, M. B. Zwick, P. W. Parren, D. R. Burton, T. Wrin, C. J. Petropoulos, J. A. Ballantyne, M. Chambers, and R. G. Whalen. (2011) A Directed Molecular Evolution Approach to Improved Immunogenicity of the HIV-1 Envelope Glycoprotein. Plos One 6:e20927.

McLellan, J. S., M. Pancera, C. Carrico, J. Gorman, J. P. Julien, R. Khayat, R. Louder, R. Pejchal, M. Sastry, K. Dai, S. O’Dell, N. Patel, S. Shahzad-ul-Hussan, Y. Yang, B. Zhang, T. Zhou, J. Zhu, J. C. Boyington, G. Y. Chuang, D. Diwanji, I. Georgiev, Y. D. Kwon, D. Lee, M. K. Louder, S. Moquin, S. D. Schmidt, Z. Y. Yang, M. Bonsignori, J. A. Crump, S. H. Kapiga, N. E. Sam, B. F. Haynes, D. R. Burton, W. C. Koff, L. M. Walker, S. Phogat, R. Wyatt, J. Orwenyo, L. X. Wang, J. Arthos, C. A. Bewley, J. R. Mascola, G. J. Nabel, W. R. Schief, A. B. Ward, I. A. Wilson, and P. D. Kwong. (2011) Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9. Nature 480:336-343.

Moldt, B., N. Schultz, D. C. Dunlop, M. D. Alpert, J. D. Harvey, D. T. Evans, P. Poignard, A. J. Hessell, and D. R. Burton. (2011) A panel of IgG1 b12 variants with selectively diminished or enhanced affinity for 2 FcγRs to define the role of effector functions in protection against HIV. J Virol 85:10572-10581.

Nicolaou, K. C., S. Sanchini, D. Sarlah, G. Lu, T. R. Wu, D. K. Nomura, B. F. Cravatt, B. Cubitt, J. C. de la Torre, A. J. Hessell, and D. R. Burton. (2011) Organic Synthesis toward Small-Molecule Probes and Drugs Special Feature: Design, synthesis, and biological evaluation of a biyouyanagin compound library. Proc Natl Acad Sci USA 108:6715-6720.

Pejchal, R., K. J. Doores, L. M. Walker, R. Khayat, P. Huang, S. K. Wang, R. L. Stanfield, A. Ramos, J. P. Julien, M. Crispin, R. Depetris, K. Y. Kang, U. Katpally, A. Marozsan, Y. Liu, R. McBride, C. Ogohara, J. Paulson, T. Feizi, C. N. Scanlan, C. H. Wong, J. P. Moore, W. C. Olson, A. B. Ward, W. R. Schief, P. Poignard, D. R. Burton, and I. A. Wilson. (2011) A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield. Science 334:1097-1103.

Scheid, J. F., H. Mouquet, B. Ueberheide, R. Diskin, F. Klein, T. Y. K. Olivera, J. Pietzsch, D. Fenyo, A. Abadir, K. Velinzon, A. Hurley, S. Myung, F. Boulad, P. Poignard, D. R. Burton, F. Pereyra, D. D. Ho, B. D. Walker, M. S. Seaman, P. J. Bjorkman, B. T. Chait, and M. C. Nussenzweig. (2011) Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding. Science 333:1633-1637.

Wahl-Jensen, V., S. Kurz, F. Feldmann, L. K. Buehler, J. Kindrachuk, V. DeFilippis, J. da Silva Correia, K. Fruh, J. H. Kuhn, D. R. Burton, and H. Feldmann. (2011) Ebola virion attachment and entry into human macrophages profoundly effects early cellular gene expression. PLoS Neglected Tropical Diseases 5:e1359.

Walker, L. M., M. Huber, K. J. Doores, E. Falkowska, R. Pejchal, J. P. Julien, S. K. Wang, A. Ramos, P. Y. C. Hui, J. L. Mitcham, P. H. Hammond, O. A. Olsen, P. Phung, S. Fling, C. H. Wong, S. Phogat, T. Wrin, M. D. Simek, P. G. P. Investigators, W. C. Koff, I. A. Wilson, D. R. Burton, and P. Poignard. (2011) Broad neutralization coverage of HIV by multiple highly potent antibodies. Nature 477:466-470.

Walker, L. M., D. Sok, Y. Nishimura, R. Pejchal, A. Ramos, M. D. Simek, Y. Geng, I. A. Wilson, P. Poignard, M. A. Martin, and D. R. Burton. (2011) Rapid development of glycan-specific, broad and potent anti-HIV-1 gp120 neutralizing antibodies in a SHIV- infected macaque. Proc Natl Acad Sci USA 108:20125-20129.

Weinfurter, J. T., G. E. May, T. Soma, A. J. Hessell, E. J. Leon, C. E. Macnair, S. M. Piaskowski, K. Weisgrau, J. Furlott, N. J. Maness, J. Reed, N. A. Wilson, E. G. Rakasz, D. R. Burton, and T. C. Friedrich. (2011) Macaque long-term nonprogressors resist superinfection with multiple CD8+ T cell escape variants of simian immunodeficiency virus. J Virol 85:530-541.

Wu, X., T. Zhou, J. Zhu, B. Zhang, I. Georgiev, C. Wang, X. Chen, N. S. Longo, M. Louder, K. McKee, S. O’Dell, S. Perfetto, S. D. Schmidt, W. Shi, L. Wu, Y. Yang, Z. Y. Yang, Z. Yang, Z. Zhang, M. Bonsignori, J. A. Crump, S. H. Kapiga, S. E. Noel, B. F. Haynes, M. D. Simek, D. R. Burton, W. C. Koff, N. Doria-Rose, M. Connors, N. C. S. Program, J. C. Mullikin, G. J. Nabel, M. Roederer, L. Shapiro, P. D. Kwong, and J. R. Mascola. (2011) Focused evolution of HIV-1 neutralizing antibodies revealed by crystal structures and deep sequencing. Science 333:1593-1602.