Publications 2010

Burton D. R. (2010) Scaffolding to build a rational vaccine design strategy. Proc Natl Acad Sci U S A. 107:17859-60.

Ng, C. T., Jaworski, J. P., Jayaraman, P., Sutton, W. F., Delio, P., Kuller, L., Anderson, D., Landucci, G., Richardson, B. A., Burton, D. R., Forthal, D. N., and Haigwood, N. L. (2010) Passive neutralizing antibody controls SHIV viremia and enhances B cell responses in infant macaques. Nat Med 16:1117-9.

Astronomo, R. D., and D. R. Burton. (2010) Carbohydrate vaccines: developing sweet solutions to sticky situations? Nat Rev Drug Discov 9:308-24.

Astronomo, R. D., E. Kaltgrad, A. K. Udit, S. K. Wang, K. J. Doores, C. Y. Huang, R. Pantophlet, J. C. Paulson, C. H. Wong, M. G. Finn, and D. R. Burton. (2010) Defining criteria for oligomannose immunogens for HIV using icosahedral virus capsid scaffolds. Chem Biol 17:357-70.

Burton, D. R., and R. A. Weiss. (2010) AIDS/HIV. A boost for HIV vaccine design. Science 329:770-3.

Doores, K. J., C. Bonomelli, D. J. Harvey, S. Vasiljevic, R. A. Dwek, D. R. Burton, M. Crispin, and C. N. Scanlan. (2010) Envelope glycans of immunodeficiency virions are almost entirely oligomannose antigens. Proc Natl Acad Sci U S A 107:13800-5.

Doores, K. J., and D. R. Burton. (2010) Variable loop glycan dependency of the broad and potent HIV-1-neutralizing antibodies PG9 and PG16. J Virol 84:10510-21.

Doores, K. J., Z. Fulton, V. Hong, M. K. Patel, C. N. Scanlan, M. R. Wormald, M. G. Finn, D. R. Burton, I. A. Wilson, and B. G. Davis. (2010) A nonself sugar mimic of the HIV glycan shield shows enhanced antigenicity. Proc Natl Acad Sci U S A.

Doores, K. J., Z. Fulton, M. Huber, I. A. Wilson, and D. R. Burton. (2010) Antibody 2G12 recognizes di-mannose equivalently in domain- and nondomain-exchanged forms but only binds the HIV-1 glycan shield if domain exchanged. J Virol 84:10690-9.

Gavrilyuk, J., H. Uehara, N. Otsubo, A. Hessell, D. R. Burton, and C. F. Barbas, 3rd. (2010) Potent Inhibition of HIV-1 Entry with a Chemically Programmed Antibody Aided by an Efficient Organocatalytic Synthesis. Chembiochem.

Hessell, A. J., E. G. Rakasz, D. M. Tehrani, M. Huber, K. L. Weisgrau, G. Landucci, D. N. Forthal, W. C. Koff, P. Poignard, D. I. Watkins, and D. R. Burton. (2010) Broadly neutralizing monoclonal antibodies 2F5 and 4E10 directed against the human immunodeficiency virus type 1 gp41 membrane-proximal external region protect against mucosal challenge by simian-human immunodeficiency virus SHIVBa-L. J Virol 84:1302-13.

Huber, M., K. M. Le, K. J. Doores, Z. Fulton, R. L. Stanfield, I. A. Wilson, and D. R. Burton. (2010) Very few substitutions in a germ line antibody are required to initiate significant domain exchange. J Virol 84:10700-7.

Pejchal, R., L. M. Walker, R. L. Stanfield, S. K. Phogat, W. C. Koff, P. Poignard, D. R. Burton, and I. A. Wilson. (2010) Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1. Proc Natl Acad Sci U S A 107:11483-8.

Reynolds, M. R., A. M. Weiler, S. M. Piaskowski, H. L. Kolar, A. J. Hessell, M. Weiker, K. L. Weisgrau, E. J. Leon, W. E. Rogers, R. Makowsky, A. B. McDermott, R. Boyle, N. A. Wilson, D. B. Allison, D. R. Burton, W. C. Koff, and D. I. Watkins. (2010) Macaques vaccinated with simian immunodeficiency virus SIVmac239Delta nef delay acquisition and control replication after repeated low-dose heterologous SIV challenge. J Virol 84:9190-9.

Scherer, E. M., D. P. Leaman, M. B. Zwick, A. J. McMichael, and D. R. Burton. (2010) Aromatic residues at the edge of the antibody combining site facilitate viral glycoprotein recognition through membrane interactions. Proc Natl Acad Sci U S A 107:1529-34.

Shedlock, D. J., M. A. Bailey, P. M. Popernack, J. M. Cunningham, D. R. Burton, and N. J. Sullivan. (2010) Antibody-mediated neutralization of Ebola virus can occur by two distinct mechanisms. Virology 401:228-35.

Walker, L. M., and D. R. Burton. (2010) Rational antibody-based HIV-1 vaccine design: current approaches and future directions. Curr Opin Immunol 22:358-66.

Walker, L. M., M. D. Simek, F. Priddy, J. S. Gach, D. Wagner, M. B. Zwick, S. K. Phogat, P. Poignard, and D. R. Burton. (2010) A limited number of antibody specificities mediate broad and potent serum neutralization in selected HIV-1 infected individuals. PLoS Pathog 6.